Studies on the influence of ingredients on fertility and professional opinions

STUDIES

on the influence of ingredients of the FertilUp food supplement for men

Oxidative stress plays a key role in male fertility and has a negative effect on sperm quality. Antioxidants have a proven positive effect on reducing oxidative stress and consequential improvement of male fertility. Various studies^1-5 have shown that antioxidants such as vitamin C, vitamin E and coenzyme Q10 have a positive influence on the treatment of male infertility as they improve both the number and motility of spermatozoa. FertilUp for men contains all three antioxidants in optimal quantities.

It has been proven that reduced levels of coenzyme Q10⁶ in seminal fluid are directly linked to asthenospermia (reduced motility of spertmatozoa) and that coenzyme Q10 reduces system defects due to antioxidative stress.

A study performed by the Glasgow Royal Infirmary⁷ in Scotland studied the influence of selenium on fertility in infertile men. Results showed that men who ingested 100 mcg of selenium per day for three months (the same dose is present in the FertilUp food supplement) experienced a significant increase in sperm motility. 11 % of the men participating in the study successfully achieved conception after three months of taking selenium (the control group that was given placebo supplements experienced no conceptions).

The role of zinc in male fertility has been confirmed by the European Commission and has a role in fertility and procreation. It also contributes to maintaining a normal level of testosterone in the blood and plays a role in cell division. A study performed by the American Society for Reproductive Medicine⁸ in 2002 sought to establish the influence of zinc and folic acid on male fertility. Results showed a substantial 74 % increase in the number of spermatozoa in a group of men with poor quality sperm, and a similar trend was also shown in fertile men. FertilUp for men contains 15 mg of zinc and 400 mcg of folate in the daily dose.

Based on the above and other studies, increased quality can be achieved through sufficient use of antioxidants, vitamins and minerals. The dietary supplement FertilUp for men contains all important antioxidants, vitamins, minerals and herbs in optimal doses with no side effects.

1. Agarwal A; Nallella KP; Allamaneni SS; Said T.M. (2004) Reprod Biomed , 8[6]:616-27

2. Balercia G; Mosca F; Mantero F; Boscaro M; Mancini A; Ricciardo-Lamonica G; Littarru G. (2004) Fertil Steril. 81[1]:93-8.

3. Suzuki M; Kurabayashi T; Yamamoto Y; Fujita K; Tanaka K. (2003) J Reprod Med, 48[9]:707-12.

4. Henmi H; Endo T; Kitajima Y; Manase K; Hata H; Kudo R. (2003) Fertil Steril.80[2]:459-61

5. Crha I; Hruba D; Ventruba P; Fiala J; Totusek J; Visnova H.Cent (2003) Eur J Public Health , 11[2]:63-7.

6. Balercia G. Arnaldi G. Fazioli F. Serresi M. Alleva R. Mancini A. et al. (2002) Andrologia 34; 107–111.

7. Scott R, MacPherson A. Selenium supplementation in sub-fertile human males. Br J Urology 1998; 82:76-80.

8. Wong; W.Y. Merkus H.M. Thomas C.M. et al. (2002) Fertil Steril 77; 491–498.

STUDIES

on the effects of FertilUp food supplement ingredients for women

Antioxidants have an important role in female fertility, as shown by numerous studies. A recent study¹ in the USA established the effects of antioxidants B-carotene, vitamin C and vitamin E on the time to conception in women. The study showed a shorter time to conception in women with a bodyweight index below 25 (normal body weight) who took vitamin C. Similarly, the time to conception was also shortened in women with a bodyweight index below 25, who took B-carotene. The study also sought to establish the effects of antioxidants on fertility in women above and below the age of 35. Increased quantities of B-carotene and vitamin C had the effect of shortening the time to conception in women under 35, while the increased quantities of vitamin E had a similar effect on women above the age of 35. FertilUp for women contains an optimal quantity of B-carotene, vitamin C and vitamin E.

A study performed in Hamburg, Germany, in 2012² also established the positive effects of vitamins C and E and also vitamin B6, vitamin D, iodine, selenium and iron.

When studying the connection between a healthy diet and fertility, the results showed that in addition to a healthy diet (less carbohydrates, processed foods), an adequate intake of vitamins B12, A, D, C and E, calcium, zinc is also important^3,4.

The results of a study focusing on the link between B vitamins and female fertility showed that women who took vitamin B supplements (especially folic acid) at least three times a week had less difficulty conceiving⁵.

FertilUp for women contains all of the above ingredients in optimal daily doses for a positive effect on female fertility.

1. Ruder E.H.; Hartmann T.J.; Reindollar R.H.; Goldman M.B. (2014) Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility

2. Buhling K.J.; Grajecki D (2012) The effect of micronutrient supplements on female fertility: a systematic review.

3. Liliana Guadalupe González-Rodríguez 1, Ana M López-Sobaler, José Miguel Perea Sánchez, Rosa M Ortega: Nutrition and fertility; • Nutr Hosp 2018 Sep 7;35(Spec No6):7-10.

4. Fumitoshi Koga, Shigeki Kitagami, Arisa Izumi, Tomoko Uemura, Osamu Takayama, Tsuyoshi Koga and Toru Mizoguchi : Relationship between nutrition and reproduction; Reprod Med Biol. 2020 Jul; 19(3): 254–264.

5. Jorge E. Chavarro, MD, ScD,a Janet W. Rich-Edwards, ScD, MPH,b,c,d Bernard A. Rosner, PhD,d,e and Walter C. Willett, MD, DrPHa,c,d : Use of multivitamins, intake of B vitamins and risk of ovulatory infertility; Author manuscript; available in PMC 2008 Sep 1.Published in final edited form as: Fertil Steril. 2008 Mar; 89(3): 668–676.

RECOMMENDATIONS FOR IMPROVING FERTILITY:

General health and lifestyle

General health of both you and your partner also affects fertility. Drink moderate amounts of alcohol and stop smoking – smoking reduces you chances of conception by at least a third, and increases the danger of miscarriage and bleeding during pregnancy. If you are physically too active, reduce physical stress. Stress can negatively affect both partners, as it postpones ovulation and influences the creation of semen.

Pay regular visits to your gynaecologist

If you have not done this so far, schedule a visit as soon as possible and check your current medical status and reproductive health. With every next visit, notify your physicians about any changes on and in your body, even if you do not think them significant. Some diseases have fairly common symptoms so they are easy to miss, but can greatly affect your fertility.

Maintain appropriate body weight

Body weight greatly influences the level of estrogen hormone, which is produced by body fat cells. If you are overweight, the estrogen level in your body is too high and has similar effect to taking contraceptives. In addition, your insulin level can increase, which in extreme cases can prevent your ovaries from releasing eggs. Being underweight can lead to a decrease in estrogen levels, which slows your reproductive cycle, or even stops it in extreme cases.

Stop smoking

Smoking has been proven to negatively affect the fertility of both men and women. Smoking is harmful to ovaries, and can even cause negative changes on the eggs, which become too susceptible to genetic abnormalities. In men, smoking affects the quantity and mobility of sperms. If you smoke, it is high time you stopped.

Practice safe sex

Various sexually transmitted inflections are among major reasons of infertility. Because symptoms are often not noticeable, the disease is not treated appropriately, which can cause changes in the body affecting fertility. For example, fallopian tubes may become scarred, which prevents the normal journey of eggs to the uterus. Use a condom and be tested regularly for sexually transmitted diseases.

Overcome stress

Stress is also one of major factors influencing fertility. While trying to get pregnant, try to relax as much as you can, avoid stressful situations, and, if possible, go on holidays. Also try – which is very difficult – not to think about the fact that you are having problems conceiving. Take trips to nature, relax, sign up for a yoga class, etc. Your state of mind plays a major role – surely you have heard stories about couples you could not get pregnant for ages but then conceived shortly after adopting a baby.

WHAT IS FERTILUP?

FertilUp is an effective solution for couple trying to get pregnant. FertilUp for men and women and natural nutritional supplements with a perfect combination of herbs, vitamins, antioxidants and minerals based on several years of research. FertilUp has been designed to increase your possibility of conception and enhance your reproductive health by creating optimal conditions in men and women for conceiving and accelerating the fertilisation stage.